Jäger & Andere

Dean Winchester - Jensen Ackles
Sam Winchester - Jared Padalecki
Bobby Singer - Jim Beaver
John Winchester - Jeffrey Dean Morgan
Ellen Harvelle - Samantha Ferris
Jo Harvelle - Alona Tal
Ash - Chad Lindberg
Gordon Walker - Sterling K. Brown
Samuel Campbell - Mitch Pileggi
Rufus Turner - Steven Williams

Dämonen

Ruby - Genevieve Padalecki
Lilith - Katherine Boecher
Meg - Rachel Miner
Azazel - Fredric Lehne
Alastair - Christopher Heyerdahl
Crowley - Mark Sheppard

Engel

Castiel - Misha Collins
Zachariah - Kurt Fuller
Uriel - Robert Wisdom
Anna Milton - Julie McNiven
Balthazar - Sebastian Roché

Erzengel

Michael - (freie Auswahl)
Gabriel - Richard Speight Jr.
Raphael - Demore Barnes
Luzifer - Mark Pellegrino

Normale Menschen

Adam Milligan - Jake Abel
Lisa Braeden - Cindy Sampson
Ben Braeden - Nicholas Elis
Bela Talbot - Lauren Cohan
Sarah Blake - Taylor Cole
Cassie Robinson - Megalyn Echikunwoke
Madison Owens - Emmanuelle Vaugier
Pamela Barnes - Traci Dinwiddie
Chuck Shurley - Rob Benedict
Becky Rosen - Emily Perkins
Lydia Stanley - Sara Canning

Ghostfacers

Harry Spangler - Travis Wester
Ed Zeddmore - A. J. Buckley

Sensenmann

Tessa - Lindsey McKeon

Die Mutter aller

Eve - Julia Maxwell

Freecharakter

(Dämon) Damian Thorian - Ian Somerhalder
(Jäger) Catherine Delvert - Nina Dobrev